It is a nootropic/sympathomimetic/energy drug that increases athletic performance, fat loss, and muscle mass.
Clenbuterol stimulates the central nervous system, hence the overlap of studies linking it to heart disease; in fact, its effect on the body is very similar to adrenaline.
Clenbuterol can increase performance (physical and cognitive); and therefore nootropic effects (smart drugs) can also be attributed to increased athletic performance. Clenbuterol is the opposite of a beta-blocker, that is, while a b-blocker reduces catecholamine production, clenbuterol increases them.
Clenbuterol and ligands
Clenbuterol is a selective drug, what does this mean? that acts on very specific receptors of the adrenergic system. Beta-2 receptors (a subtype of adrenergic receptors). Does this mean that it is the opposite of a beta-blocker? Right; while a b-blocker reduces catecholamine production, clenbuterol increases them.
Epinephrine increases cardiac output while dilating the coronary arteries, and it also has a powerful vasodilator effect on peripheral blood vessels, preparing the body for physical activity.
Clenbuterol, being so stable and functionally selective, is the most effective drug to prevent muscle wasting with the least adverse effects compared to other B-agonists. Popularly, it is only about β2 adrenergic receptors, although clenbuterol also promotes lipolysis through other receptors. Clen also has an affinity for β1 and β3 receptors.
In fact, clenbuterol also promotes lipolysis (fat burning) through the β3 receptors. The beta-3 adrenergic receptor is found primarily in brown adipose tissue and its activation has been shown to prevent or reverse obesity.
More muscle in humans with clenbuterol?
When people talk about physiology they tend to do it within a closed context of absolute values, -or it is anabolic or it is not-, this is a mistake since there are no absolute or static values in a dynamic environment like the human body.
Clenbuterol has been shown to have certain anabolic properties in humans, that is, it improves skeletal muscle function in healthy people. In patients with chronic heart failure, apart from being well-tolerated, Clen led to a significant increase in both lean muscle mass in addition to reducing the fat percentage, that is, more muscle and less fat.
Fat does not burn, it oxidizes. Lipolytic activity in adipose tissue is induced by hormonal stimulation, but we will not go into too much here; clenbuterol acts on adipocyte receptors (fat cells) accelerating the breakdown of triglycerides and increasing the availability of free fatty acids and increasing fat oxidation.
Beyond: Perilipin-sensitive lipase and hormone-sensitive lipase (LHS) are key players in fat oxidation. Clenbuterol increases intracellular levels of cyclic AMP which increases the activity of protein kinase A, which acts on LHS and perilipin.
Trials have been performed that run antagonist and agonist modes in parallel, allowing an efficient and simplified comparison between the lipolytic mechanisms of activation or inhibition of a range of compounds, clenbuterol also appears to play an important role in preventing the accumulation of adipose tissue Yes, by volume you could eat more if you use clenbuterol.
Long-term effects of Clenbuterol
A series of animal studies, given Clenbuterol for a prolonged period, have resulted in an increase in collagen in treated animals, which has led to an increase in the size of the muscle cells of the heart, reducing in this way, the efficiency in the heart’s blood pumping, causing arrhythmias, which increases the risk of suffering heart attacks, not only of the heart but also of the brain.
Other effects, which have been asserted through studies on mice that have been treated for a long time with Clen, are the degeneration of the heart cells itself, causing an enlargement of the aorta artery which would cause sudden death, hypertrophy. cardiac or heart muscle necrosis. Long-term clenbuterol can increase blood pressure and left-sided heart atrophy.
One of the effects of clenbuterol is that it causes you to lose fat and build muscle. Any product that is rumored to help us lose weight can become very popular, sometimes even at the cost of serious health risks. Clenl was already used by some bodybuilders to speed up metabolism, lose weight, and gain muscle mass.
You can see a muscular, slimmer, and firmer body and look great, what we do not know is the price that can be paid and that perhaps, this person who has used clenbuterol for several months to lose weight, in a short time may have health problems.
Despite being a very powerful and fast product, to achieve a good result, it is advisable to carry out some type of diet to try to reduce excess fat by 15%. Another important aspect is doing some kind of physical training.
You will begin by taking 1 tablet on the first day and will increase by 1 more tablet per day until you reach the seventh day, reaching 7 tablets. The second week will continue to take 7 tablets a day.
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Clenbuterol and its side effects